Methylprednisolone (MEDROL) 8 mg Tablet – 14 tablets

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Methylprednisolone (MEDROL) 8 mg Tablet is a glucocorticoid analog of prednisolone that has greater potency than prednisone. Corticosteroids binds to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and inducing anti-inflammatory signals. Each tablet contains as its active ingredient 8 mg of Methylprednisolone.

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Methylprednisolone (MEDROL) 8 mg Tablet is a glucocorticoid analog of prednisolone that has greater potency than prednisone. Corticosteroids binds to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and inducing anti-inflammatory signals. Each tablet contains as its active ingredient 8 mg of Methylprednisolone.

Drug = Methylprednisolone

Strength = 8 mg

How to take

This medicine should be taken with food or immediately after a meal and at the same time each day to avoid missing the dose. 

Take only the prescribed numbers of dose and at the prescribed duration.

Dosage of Methylprednisolone (MEDROL) 8 mg Tablet

Allergic conditions:

Adult: Day 1: 24 mg (8 mg before breakfast, 4 mg after lunch, 4 mg after supper, and 8 mg at bedtime) or 24 mg as a single or in 2-3 divided doses upon initiation (regardless of the time of day); 

Day 2: 20 mg (4 mg before breakfast, 4 mg after lunch, 4 mg after supper, and 8 mg at bedtime); 

Day 3: 16 mg (4 mg before breakfast, 4 mg after lunch, 4 mg after supper, and 4 mg at bedtime); 

Day 4: 12 mg (4 mg before breakfast, 4 mg after lunch, and 4 mg at bedtime); 

Day 5: 8 mg (4 mg before breakfast and 4 mg at bedtime); 4 mg on day 6, given before breakfast.

Anti-inflammatory or immunosuppressive:

Adult: Initially, 2-60 mg daily in 1-4 divided doses, depending on the disease being treated.

Missed Dose of Methylprednisolone (MEDROL) 8 mg Tablet

In the event that the dose is missed, take the tablet immediately and skip the dose for the day. Resume taking the medication the next day at the same time. 

Inform your doctor for dose readjustment.

Overdose of Methylprednisolone (MEDROL) 8 mg Tablet

If you took Methylprednisolone more than the prescribed dose, observe yourself for the possible side effects. If so, seek medical help.

Contraindications

People with the following medical conditions should not take Methylprednisolone:

  • Persons suffering from systemic fungal infections 
  • Patients receiving immunosuppressive therapy

Side Effects of Methylprednisolone (MEDROL) 8 mg Tablet

Methylprednisolone may have the following side effects:

  • Anaphylactic reactions
  • Kaposi’s sarcoma
  • Mood swings
  • Increased susceptibility to infection
  • Impaired wound healing
  • Elevated blood pressure
  • Peptic ulcer
  • Acne
  • Muscle weakness
  • Growth retardation

Warnings

Do not take Methylprednisolone with the following medicines:

  • Aminoglutethimide 
  • Amphotericin B
  • Diuretics
  • Macrolide antibiotics
  • Isoniazid
  • Cholestyramine
  • Ciclosporin
  • Digitalis glycosides
  • Estrogens
  • Oral Contraceptives
  • Rifampicin
  • Barbiturates
  • Ketoconazole
  • Erythromycin
  • Aspirin
  • NSAIDs
  • Warfarin
  • Antidiabetics

Potentially Fatal: 

  • Live, attenuated vaccines

Inform your physician if you are taking medications which are off label drugs and vitamin supplements that can be bought over the counter.

How Does It Work?

In order to facilitate anti-inflammatory signals and suppress pro-inflammatory signals, methylprednisolone stimulates and binds to intracellular glucocorticoid receptors. High corticosteroid doses have an immunosuppressive effect, while lower doses have anti-inflammatory properties.

Uses 

Methylprednisolone is used to treat the following conditions:

  • Allergic reactions
  • Anti-inflammatory or immunosuppressive

Special Precautions and Warnings

Take special precautions if you have the following conditions:

  • Patient with heart failure
  • Hypertension
  • Diabetes Mellitus
  • Peptic ulcer
  • Previous history of heart attack
  • Cataracts
  • Osteoporosis
  • History of seizure disorder
  • Thyroid disease
  • Renal and hepatic impairment (including cirrhosis)
  • Children
  • Pregnant and lactating mothers

Storage Conditions

  • Store between 20-25°C.
  • Store in a cool, dry place away from the reach of children.
  • Do not use Methylprednisolone that is expired or out of date.